----Are you familiar the customs here?--No the place is unfamiliar me.A with; wit

问题补充：

----Are you familiar the customs here?

----No, the place is unfamiliar me.

A with; with

B with; to

C to; to

D to ; with

答案：

解析：考查情景交际和固定搭配。“你对这里的风俗熟悉吗？”“不，这个地方对我来说不熟悉。”sb. be familiar with sth.“某人对某物熟悉”；sth. be familiar to sb.“某物对某人来说很熟悉”。故选B。