Wnt/β-catenin信号转导通路,Wnt/β-catenin signaling pathway
1)Wnt/β-catenin signaling pathwayWnt/β-catenin信号转导通路
1.Objective: The inhibition effect of periplocin extracted from cortex periplocae (CPP) on proliferation of human colon carcinoma cell line SW480 in vitro and in vivo was studied, and the regulation effect of CPP onWnt/β-catenin signaling pathway and its downstream target genes was investigated.目的:观察香加皮杠柳苷(periplocin extracted from cortex periplocae, CPP)对人结肠癌细胞株SW480在体内外增殖的抑制作用,研究其对SW480细胞内Wnt/β-catenin信号转导通路的调控作用和对β-catenin/TCF下游靶基因的影响,以探讨CPP的抗肿瘤作用机制,为CPP作为抗肿瘤药物开发提供理论依据。
英文短句/例句
1.The Relationship between the Hepatitis B Virus X Protein and β-Catenin;HBX对Wnt/β-catenin信号转导通路的影响研究
2.Research on the Relationship between Wnt/β-catenin Pathway Activation and Human Ovarian CarcinomaWnt/β-catenin信号转导通路与卵巢癌的相关研究
3.Effect of Quercetin on Proliferation of Human Colorectal Cancer Cell Line and on Wnt/β-catenin Signaling Pathway;槲皮素对结肠癌细胞抑制作用及对Wnt/β-catenin信号转导通路的影响
4.Wnt/β-catenin Signal Pathway and Malignant Hematological Disease--ReviewWnt/β-catenin信号通路与恶性血液病
5.The Effect of Octreotide on Colonic Cancer Cell SW480 and Its Wnt/β-Catenin Signal Transduction Pathway in Vitro;奥曲肽对结肠癌细胞SW480及Wnt/β-catenin信号传导通路的影响
6.The Activation and Role of WNT/β-Catenin Signaling Transduction Way in Leukemia Cells;Wnt/β-catenin信号转导途径在白血病细胞中的激活及作用
7.Primary Research on the Effects of Wnt/β-catenin Signalling on Pig Satellite Cells Proliferation and Differentiation;Wnt/β-catenin信号通路对猪肌卫星细胞增殖分化影响的初步研究
8.Regulation of Wnt/Beta-Catenin Signal Pathway during Porcine Adipose Tissue Development;Wnt/β-catenin信号通路在猪脂肪组织发育过程中的调控作用
9.Wnt/β-Catenin Signaling Contributes to Activation of Normal and Tumorigenic Liver Progenitor Cells;Wnt/β-Catenin信号通路对正常和肿瘤性肝前体细胞活化的调节
10.Experimential Study on the Canonical Wnt/β-catenin Pathway in Intervertebral Disc Degeneration经典Wnt/β-catenin信号通路在椎间盘退变中的作用及机制研究
11.The Role of Wnt/Beta-catenin Signaling Pathway Hypofunction in Diabetic Patients with Impaired Wound HealingWnt/β-catenin信号通路功能低下在糖尿病合并创面难愈中的作用
12.Studying on the Relevance Between Aging Kidney-Yang Deficiency Syndrome and the Wnt/β-catenin Signaling Pathway by cDNA Microarray Assay运用基因芯片技术分析老龄肾阳虚证与Wnt/β-catenin信号通路的相关性
13.Pathogenesis of osteoarthritis and its relationship with the Wnt/β-catenin pathway骨性关节炎的发病机制及其与Wnt/β-catenin信号通路的关系
14.Identification of Wnt/β-catenin Signal Pathway in Human Prostate Cancer Cell Lines and Its SignificanceWnt/β-catenin信号通路在多种人前列腺癌细胞系中的表达研究及意义
15.Effects of Wnt/β-catenin signals on the callus modelling and the biomechanical properties of the fractured tibia in miceWnt/β-catenin信号通路对小鼠骨痂塑形和生物力学性能的影响
16.Studies on the Effects of NGX6 Gene in Wnt/Beta-catenin Signaling Pathway;NGX6基因在Wnt/Beta-catenin信号传导通路中的作用机制研究
17.Glutamine synthetase and Wnt-signaling谷氨酰胺合成酶与Wnt信号转导通路
18.Varp Interacts with LRP6 and Negatively Regulates Wnt/b-catenin Signaling Pathway;Varp与LRP6相互作用抑制性调控Wnt/b-catenin信号通路
相关短句/例句
Wnt/β-catenin signaling pathwayWnt/β-catenin信号通路
1.Expression of β-catenin,Survivin and C-myc involved inWnt/β-catenin signaling pathway were detected by immunohistochemistry.材料与方法:将SW480细胞经皮下接种Balb/c-nu/nu裸小鼠,构建裸鼠SW480细胞荷瘤动物模型,观察CPP作用后移植瘤体积和重量的变化,HE染色光镜下观察移植瘤组织形态学变化,免疫组织化学方法检测瘤组织内Wnt/β-catenin信号通路中核心成分β-catenin及其下游靶蛋白Survivin和C-myc表达的变化。
3)WNt/β-catenin signaling pathwayWNT/β-catenin信号转导途径
4)Wnt/β-cateninWnt/β-catenin信号
1.Effects ofWnt/β-catenin signals on the callus modelling and the biomechanical properties of the fractured tibia in miceWnt/β-catenin信号通路对小鼠骨痂塑形和生物力学性能的影响
5)Wnt/β-catenin pathwayWnt/β-catenin通路
1.[Objective]To investigate the expression of β-catenin and β-catenin/Tcf complex, two key members in theWnt/β-catenin pathway, in different differentiated nasopharyngeal carcinoma (NPC ), and elucidate the role ofWnt/β-catenin pathway in neoplastic cells differentiation of NPC.【目的】探讨Wnt/β-catenin通路的枢纽分子β-catenin和β-catenin/Tcf复合体在不同分化程度鼻咽癌中的表达,进而阐明Wnt/β-catenin通路对鼻咽癌分化的作用。
6)Wnt signaling pathwayWnt信号转导通路
1.Curcumin inhibits proliferation of lung cancer cell A549 throughWnt signaling pathway;姜黄素通过Wnt信号转导通路抑制肺癌细胞A549增殖的研究
2.Many research results showed thatβ-catenin played an important role inWnt signaling pathway and was the key intraceUular component of E-cd/cat complex involved in intercellular adhesion and link.多项研究结果显示β-连环素是Wnt信号转导通路的关键调控点并是构成粘附连接的E-cd/cat复合体的胞内重要组份,并通过与多种蛋白的结合参与肿瘤的发生发展、增殖分化、侵袭转移等生物学过程。
3.Wnt signaling pathway is initiated by the secreted Wnts pro -teins.Wnt信号转导通路,即由Wnt基因编码产物所介导的信号转导通路,其不仅在胚胎发育调控中起至关重要的作用,而且与肿瘤的发生、发展也密切相关。
延伸阅读
β-catenin分子式：CAS号：性质：原癌基因编码的蛋白质，参与钙依黏附蛋白(cadehrin)胞内结构域介导的信号转导的重要分子。正常细胞内它的浓度较低。在由它介导信号转导的结果中都发现APC(adenomatous polyposis coli，是一种肿瘤抑制蛋白质)，是一个β-连蛋白信号转导的负调节剂。显然β-连蛋白在恶性肿瘤病因研究领域中占有相当重要的地位。一旦APC或β连蛋白发生突变，即可发生信号转导减弱，细胞增殖加快与抑制细胞凋亡等作用，这是至今所了解的正常细胞发生恶变的β-连蛋白作用分子机制。
