糖基异硫氰酸酯,glycosyl isothiocyanate
1)glycosyl isothiocyanate糖基异硫氰酸酯
1.Fifteen target compounds were synthesized with the following three steps: amino acids were protected to form carbobenzoxyamino acid methyl esters, the carbobenzoxyamino acid methyl esters reacted with hydrazine to give carbobenzoxy amino acid hydrazides, and treatment of the carbobenzoxy amino acid hydrazides withglycosyl isothiocyanates afforded 3a～3o in 65%～86% yields.通过对5种氨基酸酯化和氨基保护得到苄氧羰基氨基酸甲酯,经肼解制备苄氧羰基氨基酸酰肼,然后分别与3种不同的糖基异硫氰酸酯反应,制备了相应的目标化合物15个,且产率均在60%以上。
2.The reaction of 2 withglycosyl isothiocyanates 3～5 gave the novel compounds, N-glycosyl-N"-amido thioureas 6～8.以L-α-氨基酸为起始原料,经酯化、氨基保护、肼解制得N-对甲苯磺酰基-L-α-氨基酸酰肼2,再与糖基异硫氰酸酯3～5反应,得到9种新型N-糖基-N"-酰氨基硫脲6～8,然后在Hg(OAc)2/EtOH条件下关环,合成了一系列新的2-对甲苯磺酰氨基烃基-5-糖氨基-1,3,4-噁二唑类化合物9～11。
3.Theglycosyl isothiocyanates 1a～1c reacted with anhydrous hydrazine gave N-glycosyl- N"-aminothioureas 2a～2c, which then reacted further with 6-substituted-3-formylchromones 3a～3d to give a series of new N-glycosyl-N′-6-substitutedchromon-3-ylmethylideneaminothioureas 4a～4d, 5a～5d, 6a～ 6d.糖基异硫氰酸酯(1a～1c)与无水肼反应,生成糖基氨基硫脲2a～2c,再与6-取代-3-甲酰基色酮3a～3d反应,得到一系列新的N-糖基-N′-(6-取代色酮-3-基-亚甲氨基)硫脲类化合物4a～4d,5a～5d,6a～6d。
英文短句/例句
1.Synthesis and Application of 2,3,4,6-Tetra-O-acetyl-β-D-glycosyl Isothiocyanate2,3,4,6-四-O-乙酰基-β-D-吡喃葡萄糖基异硫氰酸酯合成方法的改进
2.As a kind of important intermediates, glycosyl isothiocyanates have been applied in the preparation of new compounds possessing considerable bioactivities.作为一类重要的有机合成中间体，糖基异硫氰酸酯广泛地应用于具有生理活性化合物的制备。
3.phenyl mustard oi苯基芥子油,异硫氰酸苯酯
4.Environmental novel synthesis technology for 3,4-diflorophenyl isothiocyanate合成3,4-二氟苯基异硫氰酸酯的绿色工艺
5.methyl diphenylene diisocyanate二苯基甲基二异氰酸酯
6.MDI(4,4"-diphenylmethane diisocyanate)-二苯基甲烷二异氰酸酯
7.triphenylmethane triisocyanate三苯基甲烷三异氰酸酯
8.Method for determination of isothiocyanates in feedsGB/T13087-1991饲料中异硫氰酸酯的测定方法
9.On R-NCS cancer chemopreventative properties;异硫氰酸酯的抗癌活性与结构的关系
10.Studies on Purification and Antitumor in Vitro Experiment of Iberin3-甲磺酰基丙基异硫代氰酸酯的提取分离与抗肿瘤的体外试验
11.Phenylhexyl isothiocyanate induces gene p15 demethylation by down-regulating DNA methyltransferases in Molt-4 cells异硫氰酸苯己酯诱导Molt-4细胞p15基因去甲基化及机制研究
12.De Novo Sequence of Novel Protein Based on Chemically-assisted Method Using 4-Sulfophenyl Isothiocyanate Derivatization by Mass Spectrometry磺基异硫氰酸苯酯化学辅助方法对新蛋白质进行从头测序
13.Study on the Semi-synthesis of Tripthiocyanatolide雷公藤硫氰酸基内酯醇的半合成研究
14.Active Comparison of Isocyanates in Isophorone Diisocyanatek异佛尔酮二异氰酸酯分子中异氰酸酯基团活性比较
15.isopropylphosphoramidothioic acid ester硫代氨基磷酸异丙酯
16.Hexamethylene diisocysnate (HMDI) may be used in prepolymer, in place of TD I.六亚甲基二异氰酸酯（HMDI）可用在预聚物中代替甲苯二异氰酸酯〔TOI〕。
17.Hexamethylene diisocyanate (HMDI) may be used in prepolymer, in place of TDI.六亚甲基二异氰酸酯（HMDI）可用在预聚物中代替甲苯二异氰酸酯〔tdi〕。
18.Studies on dynamic phase equilibriums of Isothiocyanates adsorbed in macroporous resin大孔树脂吸附异硫氰酸酯的动态相平衡研究
相关短句/例句
lactosyl isothiocyanate乳糖基异硫氰酸酯
1.The reaction of 2,3,6,2",3",4",6"-hepta-O-acetyl-β-lactosyl isothiocyanate (1) with 2-amino-4/6-substituted benzothiazoles 2a-2e gave lactosylthioureas 3a-3e, which were treated with amines in the presence of HgCl2 to afford a series of novel N-alkyl/aryl-N"-(4/6-substituted benzothiazol-2-yl)-N""-perace-tylated lactosylguanidines 4-6.6"-七-O-乙酰基-β-乳糖基异硫氰酸酯(1)分别与2-氨基-4/6-取代苯并噻唑2a～2e反应,制得糖基硫脲3a～3e,将其在HgCl2作用下与伯胺反应,制得一系列新化合物N-烷基/芳基-N"-(4/6-取代-苯并噻唑-2-基)-N""-(2,3,6,2",3",4",6"-七-O-乙酰基-β-乳糖基)胍4～6。
3)rhamnosyl isothiocyanate鼠李糖基异硫氰酸酯
1.The nucleophilic addition ofrhamnosyl isothiocyanate to substituted 2-aminobenzothiazoles (2a～2f), 2-hydrazinobenzothiazoles (2g～2l), oxidized and nonoxidized 3-hydra- zinocarbon.以L-鼠李糖为起始原料,制备1-溴-2,3,4-三-O-乙酰基-β-L-吡喃型鼠李糖,然后在甲苯中与Pb(SCN)2作用,得到中间体2,3,4-三-O-乙酰基-α-L-吡喃型鼠李糖基异硫氰酸酯(1)。
4)glucosyl isothiocyanate葡萄糖基异硫氰酸酯
1.Refluxing of 2 withglucosyl isothiocyanate(1)in CHCl_3 gave corresponding N,N′-substituted-N″-(2,3,4,6-tetra-O-acetylglucosylthioureylene)phosphoric triamides(3a-3g),and deacetylation in MeOH/NaOMe gave N,N"-substituted-N″-glucosy1 thioureylene phosphoric triamides(4a-4g).将它们与葡萄糖基异硫氰酸酯在氯仿中回流 ,生成相应的N 芳基 (烷基 ) N′ 芳基 (烷基 ) N″ 2 ,3,4,6 四 O 乙酰基葡萄糖基硫代亚脲基膦酰三胺 ( 3a 3g) ,然后在甲醇甲醇钠中脱去乙酰基得到目标化合物N 芳基 (烷基 ) N′ 芳基 (烷基 ) N″ 葡萄糖基硫代亚脲基膦酰三胺 ( 4a 4g)。
5)xylopyranosyl isothiocyanate木吡喃糖基异硫氰酸酯
1.The reaction of 2,3,4-tri-O-acetyl-β-D-xylopyranosyl isothiocyanate 1 and 2-amino-4/6-substituted benzothiazoles 2a～2e gave xylopyranosylthioureas 3a～3e,which then reacted with alkyl/aryl amine in the presence of HgCl_2 to afford a series of new guanidinoxylopyranosides (4a～4e,5a～5e,6a～6e and 7a～7e).2,3,4-三-O-乙酰基-β-D-木吡喃糖基异硫氰酸酯1与2-氨基-4/6-取代-苯并噻唑2a～2e反应,生成糖基硫脲衍生物3a～3e,再在伯胺存在下经氯化汞脱硫,得到一系列新的胍基木吡喃糖苷类化合物4a～4e,5a～5e,6a～6e,7a～7e,所有新化合物的结构均经IR,~1H NMR,MS谱和元素分析证实,所得产物均为β-构型。
6)glycosyl isothiocyanate糖基异硫氰酸脂
延伸阅读
硫氰酸钙国标编号 61501 CAS号 2079-16-2分子式 CaSCN 分子量 98.16无色晶体;蒸汽压;熔点;溶解性:溶于水、乙醇;密度;稳定性：稳定;危险标记 14(有毒品);主要用途：主要用于印染工业，化学分析 2.对环境的影响:一、健康危害侵入途径：吸入、食入。健康危害：其毒作用与氰化物不同。无剧毒。急性中毒：动物出现呼吸困难、痉挛、腹泻、血压降低，然后血压升高，心脏活动障碍，可在一昼夜内死亡。慢性中毒：出现甲状腺的损伤。二、毒理学资料及环境行为危险特性：受高热分解放出有毒气体。燃烧(分解)产物：硫化物、氰化氢。3.现场应急监测方法:4.实验室监测方法:借硫氰酸铜的热分解作用测定毫克量硫氰酸盐的方法[刊，波兰]/Majewski T.；Cyganske A.//Chem.Anal. (Warsaw).-1986，31(5/6).-811～818 《分析化学文摘》1989.35.环境标准:6.应急处理处置方法:一、泄漏应急处理隔离泄漏污染区，周围设警告标志，建议应急处理人员戴好防毒面具，穿相应的工作服。不要直接接触泄漏物，用大量水冲洗，经稀释的洗水放入废水系统。如大量泄漏，收集回收或无害处理后废弃。二、防护措施呼吸系统防护：空气中浓度较高时，应该佩带防毒面具。紧急事态抢救或逃生时，佩带自给式呼吸器。眼睛防护：一般不需特殊防护。必要时戴安全防护眼镜。身体防护：穿相应的防护服。手防护：戴防化学品手套。其它：工作现场禁止吸烟、进食和饮水。工作后，彻底清洗。单独存放被毒物污染的衣服，洗后再用。保持良好的卫生习惯。三、急救措施皮肤接触：立即用流动清水彻底冲洗。就医。眼睛接触：立即提起眼睑，用大量流动清水彻底冲洗。吸入：迅速脱离现场至空气新鲜处。必要时进行人工呼吸。就医。食入：误服者给饮大量温水，催吐，就医。灭火方法：雾状水。
