扁桃酸对映体,mandelic acid enantiomer
α-Cyclohexyl-mandelic acid enantiomersα-环己基扁桃酸对映体
3)p-Bromophenylglycolic acid对溴扁桃酸
4)p-chloro-phenylglycollic acid对氯扁桃酸
5)4-Fluoro-alpha-hydroxyphenylacetic acid对氟扁桃酸
6)p-propoxy mandelic acid对丙氧基扁桃酸
1.2∶1 at a reaction temperature of 100 ℃ and a reaction time of 30 min to give 2,which was then subjected to condensation reaction withp-propoxy mandelic acid in the presence of phosphoric acid at a molar ratio of m(2)∶m(p-propoxy mandelic acid)∶m(phosphoric acid)=1∶1∶1 at a reaction temperature of 60 ℃ for 3 h to yield 3,which was further oxidized by chloranil to give t.2∶1投料,100℃反应30 min得缩合物2,再在等质量磷酸催化下与分批加入的等质量对丙氧基扁桃酸60℃缩合3 h得缩合物3,经温和氧化剂四氯苯醌氧化得标题化合物,总收率55%。
延伸阅读
慢性扁桃体炎慢性扁桃体炎chronic tonsillitis扁桃体窝易储存细菌及分泌物，细菌毒素经腺窝周围的血管网传播到周身。因而扁桃体成为不少全身性疾病如风湿热、肾炎等的病灶。
